Formic Acid → HCID 14987947, compound

Participants

Reaction Steps

A mixture of 1.50 g of methyl 6-homopiperazinylnicotinate (compound 13), 0.68 g of 35% formaldehyde and 1.2 g of formic acid was stirred at 70°-80° C. for 2 hours. The resulting mixture was poured into 120 ml of water and extracted with ethyl acetate. The extract was washed twice with water and once with a saturated aqueous sodium chloride solution, then dried over anhydrous magnesium sulfate and concentrated. Purification of the concentrate by column chromatography (silica gel; ethyl acetate : methanol=1:2) gave 1.35 g of methyl 6-(4-methyl-1-homopiperazinyl)nicotinate (yield 85%).

Provenance & Evidence