Phosphorus oxychloride → HCID 14515836, compound

Participants

Reaction Steps

2.7 g of 7-chloro 4-hydroxy 3-isonicotinoyl quinoline are added under nitrogen to 60 ml of POCl3 and refluxed for 5 hours. After being filtered off, the precipitate is poured onto ice. The aqueous solution is made alkaline with sodium carbonate before the chlorinated derivative is extracted into dichloromethane: crystals (isopropyl ether). M.p.=132° C. (Yield 53%).

Provenance & Evidence