Oxalic acid dihydrate → HCID 19827847, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.5 g (2.1 mmol) N-benzyl-2-amino-4-nitroaniline and 0.55 g (4.4 mmol) oxalic acid dihydrate in 30 ml 4N hydrochloric acid was refluxed for 5 h. After cooling to 25° C. the product was filtered off and washed with water. The crude product was recrystallized (dimethylformamide-water), washed with 10 ml water, 5 ml ethanol and 5 ml ether to give 0.3 g (49%) 1-benzyl-6-nitroquinoxaline-2,3(1H,4H)-dione. M.p. (DSC): 292.2° C. 1H-NMR (DMSO-d6): 12.4 (1H, broad s), 8.2-7.0 (8H, m), 5.4 (2H, s).

Provenance & Evidence