Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 12793832 | HCID 12793832 | 82.6% |
Reaction Steps
A solution of 5.0 g (31 mmol) 2.5-difluoronitrobenzene, 3.8 ml (31 mmol) cyclohexylamine and 4.4 ml (31 mmol) triethylamine in 50 ml dimethylformamide was stirred at 80° C. for 2 h. After cooling to 25° C. 100 ml water was added. The precipitate was filtered off and washed with water to give 6.1 g (82%) N-cyclohexy-4-fluoro-2-nitroaniline. M.p. 93.0° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05026704 |
|---|
| Source dataset | uspto-grants-1991_06 |
|---|
| ORD ID | ord-ae3c3495d3e54894ba2464f64641ed46 |
|---|
| Source note | uspto-grants-1991_06 |
|---|
