2-Methylimidazole → HCID 13764026, compound

HRID 1494364Notes

Reaction equation

HRID 1494364 reaction equation
Cl[CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH3:15])=[CH:9][CH:8]=1)=O.[CH3:16][C:17]1[NH:18][CH:19]=[CH:20][N:21]=1>>[CH2:14]([O:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]2[C:19]3[N:18]([C:17]([CH3:16])=[N:21][CH:20]=3)[CH2:2][CH2:3][CH:4]=2)=[CH:8][CH:9]=1)[CH3:15]

Participants

3

Reactant 2

HCID 127492-MethylimidazoleHCID 12593900HCID 12593900, compound

Product 1

HCID 13764026HCID 13764026, compound

Procedure

Combine 150 g (0.66 mol) of 4-chloro-4'-ethoxybutyrophenone with 300 g (3.65 mol) of 2-methylimidazole and heat to 175° C. for 18 hr. Crystallization from ethyl acetate provides the title compound.

Workup

  1. customCrystallization from ethyl acetate

Sources & evidence

ORD record
ord-2ab66c88849a49cda6d82c4911162034
Source dataset
uspto-grants-1991_06
Patent number
US05026712

Reaction notes

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