2-Methylimidazole → HCID 13764022, compound

HRID 1494368Notes

Reaction equation

Cl[CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=1)=O.[CH3:14][C:15]1[NH:16][CH:17]=[CH:18][N:19]=1>>[CH3:14][C:15]1[N:19]2[CH2:2][CH2:3][CH:4]=[C:5]([C:7]3[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=3)[C:18]2=[CH:17][N:16]=1

Participants

Reactant 2

HCID 127492-Methylimidazole

HCID 987454-Chloro-4'-methylbutyrophenone

Product 1

HCID 13764022HCID 13764022, compound

Procedure

Combine 50 g (0.25 mol) of 4-chloro-4'-methylbutyrophenone with 124 g (1.5 mol) of 2-methylimidazole and heat to 175° C. for 70 hr. Crystallize from ether to provide the title compound.

Workup

customCrystallize from ether

Sources & evidence

ORD record: ord-2ea1f57acf8f4829b4416a9881ba749e
Source dataset: uspto-grants-1991_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05026712

Reaction notes

Loading…