HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-(2-Fluorophenyl)acetyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Benzeneacetic acid, 2-fluoro- | HCID 67979 | — |
| Product | 2-(2-Fluorophenyl)acetyl chloride | HCID 14004011 | 68.5% |
Reaction Steps
o-Fluorophenylacetic acid (35.9 g; 0.233 mmol) was stirred in 40 ml of thionyl chloride for 24 hours at room temperature. Volatile material was removed in vacuo to obtain a yellow, mobile liquid. The liquid was distilled in vacuo to obtain 27.45 g (68.5%) of o-fluorophenylacetyl chloride as a colorless liquid, b.p. 85° C. (4 mm Hg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05026707 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-48b7744d8964412fac6950d147e68350 |
| Source note | uspto-grants-1991_06 |