反应详情

The tetrahydronaphthalene (2.1 g; 10.1 mmol) was dissolved in 20 ml of methylene chloride. The resulting solution was added to a solution of 3.27 g (15.2 mmol) of pyridinium chlorochromate in 60 ml of methylene chloride. The mixture was stirred for seven hours at room temperature and then was filtered through a bed of Celite. The filtrate was evaporated in vacuo to a dark, viscous residue. The residue was dissolved in methylene chloride and placed on a flash silica column. The column was eluted with methylene chloride, and the eluate was evaporated in vacuo to give 0.8 g (38.4%) of 5,8-dimethoxy-2-tetralone as a gold, crystalline solid.

1. filtrationwas filtered through a bed of Celite
2. customThe filtrate was evaporated in vacuo to a dark, viscous residue
3. dissolutionThe residue was dissolved in methylene chloride
4. washThe column was eluted with methylene chloride
5. customthe eluate was evaporated in vacuo