Water → HCID 54088569, compound

Participants

Reaction Steps

The dimethoxytetralone (0.4 g; 1.94 mmol) was dissolved in 10 ml of toluene. To the solution were added 0.46 ml (4 mmol) of N-methylpiperazine followed by 0.91 g (4.8 mmol) of p-toluenesulfonic acid. The mixture was stirred for 31/2 hours at reflux under nitrogen with constant water removal. The mixture then was cooled to room temperature, and the volatile material was removed in vacuo to give 3-(N-methylpiperazinyl)-5,8-dimethoxy-1,2-dihydronaphthalene as an orange-brown residue.

Provenance & Evidence