HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → 3-Pyrrolidino-5-chloro-1,2-dihydronaphthalene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 8-Chloro-1,2,3,4-tetrahydronaphthalen-2-one | HCID 4623269 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Pyrrolidino-5-chloro-1,2-dihydronaphthalene | HCID 15137221 | 92.3% |
Reaction Steps
To 100 ml of toluene were added 5.0 g (27.8 mmol) of 8-chloro-2-tetralone. To the resulting solution then were added 3.5 g of pyrrolidine, and the mixture was heated to reflux for three hours after which the solvent was removed in vacuo to give 3-pyrrolidino-5-chloro-1,2-dihydronaphthalene as a dark oil (about 6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05026707 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-73c875ca456145bf8466078f01331da0 |
| Source note | uspto-grants-1991_06 |