m-Chloroperbenzoic acid → HCID 3076390, compound

Participants

Reaction Steps

m-Chloroperbenzoic acid (0.6 g) is added in the course of approximately 10 minutes to 2-imino-3-(2-phenylthioethyl)-6trifluoromethoxybenzothiazoline (1.3 g) in absolute ethanol (20 cc) cooled to 0.C. The reaction is continued for 3 hours at a temperature in the region of 20 C. The reaction medium is concentrated to dryness under reduced pressure (20 mm Hg; 2.7 kPa) and the residue obtained purified by chromatography on a silica column with ethyl acetate as eluent. (RS)-2-Imino-3-(2-phenylsulphinylethyl)-6-trifluoromethoxybenzothiazoline (0.7 g) is obtained in the form of a yellowish oil, which is converted to a hydrochloride, m.p. 10 C.

Provenance & Evidence