Potassium Hydroxide → HCID 178422989, compound

HRID 1494417Notes

Reaction equation

HRID 1494417 reaction equation
Br.[CH3:2][C:3]1[N:4](S(C2C=CC=CC=2)(=O)=O)[CH:5]=[C:6]([C:8]2[N:9]=[C:10]([NH:13][C:14]([NH2:16])=[NH:15])[S:11][CH:12]=2)[CH:7]=1.[OH-].[K+]>CO>[CH3:2][C:3]1[NH:4][CH:5]=[C:6]([C:8]2[N:9]=[C:10]([NH:13][C:14]([NH2:16])=[NH:15])[S:11][CH:12]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 178419503HCID 178419503, compound

Product 1

HCID 178422989HCID 178422989, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 12.1 g (25 mmole) of N-[4-(2-methyl-1-phenylsulfonylpyrrol-4-yl)thiazol-2-yl]guanidine hydrobromide, 12.1 g 85% potassium hydroxide and 400 ml methanol was heated at reflux for 18 hours. The mixture was cooled, evaporated to dryness, and the residue triturated with water. The resulting precipitate was collected, washed with water, and dried in vacuo to give 5.3 g (96%) of the product as its free base; m.p. 235°-237° C.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 18 hours
  3. temperatureThe mixture was cooled
  4. customevaporated to dryness
  5. customthe residue triturated with water
  6. customThe resulting precipitate was collected
  7. washwashed with water
  8. customdried in vacuo

Sources & evidence

ORD record
ord-7a932002ab664697a48b0870506298ef
Source dataset
uspto-grants-1991_06
Patent number
US05026715

Reaction notes

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