2-bromo-1-(1H-indol-2-yl)ethanone → HCID 178419714, compound

HRID 1494419Notes

Reaction equation

HRID 1494419 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10](=O)[CH2:11][Br:12].[C:14]([NH:17][C:18]([NH2:20])=[S:19])(=[NH:16])[NH2:15]>>[BrH:12].[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]1[N:20]=[C:18]([NH:17][C:14]([NH2:16])=[NH:15])[S:19][CH:11]=1

Participants

3

Reactant 2

HCID 3193812-bromo-1-(1H-indol-2-yl)ethanoneHCID 178513045HCID 178513045, compound

Product 1

HCID 178419714HCID 178419714, compoundYield 80.4%

Procedure

By reaction of 1.31 g (5.48 mmole) 1-(1H-indol-2-yl)-2-bromoethanone with 0.65 g (5.53 mmole) guanylthiourea by the method of Example 10 afforded 1.49 g (80%) of the title salt; m.p. 309°-310° C. (decomp.).

Sources & evidence

ORD record
ord-154721bc77014b55aef8070517d01027
Source dataset
uspto-grants-1991_06
Patent number
US05026715

Reaction notes

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