Diethyl Ether → 1-(4-Fluorophenyl)ethanol

HRID 1494435Notes

Reaction equation

HRID 1494435 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5](CC(C2C=CC=CC=2)=O)=[CH:4][CH:3]=1.[BH4-].[Na+].C([O:21][CH2:22][CH3:23])C>C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:22]([OH:21])[CH3:23])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 2363292-(4-fluorophenyl)-1-phenylethanoneHCID 4311764Sodium borohydride

Product 1

HCID 739461-(4-Fluorophenyl)ethanol

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-(4-Fluorophenyl)ethanol was prepared by mixing 10 g (72 mmol) of 4-fluorophenylacetophenone and 2.74 g (72 mmol) of sodium borohydride in 100 mL of ethanol. After one hour the solvent was removied under vacuum and the residue was taken up in diethyl ether. The ether solution was dried over anhydrous magnesium sulfate and evaporated to yield the crude product which was used without further purification.

Workup

  1. dry with materialThe ether solution was dried over anhydrous magnesium sulfate
  2. customevaporated

Sources & evidence

ORD record
ord-9c54ec95f2104271b6c54f81db542827
Source dataset
uspto-grants-1991_06
Patent number
US05026729

Reaction notes

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