Acetyl chloride → HCID 14673827, compound

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Reaction Steps

N-Hydroxy-N-(1-(4-(1-(4-fluorophenyl)ethoxy)-phenyl)ethyl]acetamide was prepared by the reaction of the hydroxylamine compound prepared in step (d) above with two equivalents of acetyl chloride in the presence of triethylamine in THF. The intermediate N,O-diacetyl compound was extracted with ethyl acetate, dried over anhydrous magnesium sulfate, after which the solvent was evaporated. The residue was taken up in isopropyl alcohol and a solution of lithium hydroxide in water was added. The mixture was stirred until the reaction was complete, and then neutralized by the addition of 2N HCl. This mixture was extracted with ether, the ether solution dried over anhydrous magnesium sulfate, and evaporated to yield the title compound.

Provenance & Evidence