HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Thioglycolate → HCID 19828249, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Thioglycolate | HCID 16907 | — |
| Reactant | Lithium amide | HCID 24532 | — |
| Reactant | 1-Cyclohexyloxy-2,2,6,6-tetramethyl-piperidin-4-ol | HCID 11322811 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 19828249 | HCID 19828249 | — |
Reaction Steps
1-Cyclohexyloxy-2,2,6,6-tetramethylpiperidin-4-ol a (25.5 grams, 0.1 mol) and methyl thioglycolate (10.6 grams, 0.11 mol) are dissolved in toluene. Lithium amide (0.09 mol) is added and the reaction mixture is heated under reflux and the distillate collected in a Dean-Stark trap. After heating under reflux overnight, the toluene is removed under reduced pressure. Acetic acid is added to neutralize the basic catalyst. The crude reaction product is purified by liquid chromatography to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05026750 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-2953087d3daf445a9af5f927cbeffd61 |
| Source note | uspto-grants-1991_06 |