HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → N-butyltrifluoroacetyl-2,4-difluoroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Butyl methanesulfonate | HCID 15953 | — |
| Reactant | N-(2,4-difluorophenyl)-2,2,2-trifluoroacetamide | HCID 4517860 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | N-butyltrifluoroacetyl-2,4-difluoroaniline | HCID 54338454 | 53.4% |
Reaction Steps
A mixture of 60.8 g of n-butyl methanesulphonate and 22.5 g of trifluoroacetyl-2,4-difluoroaniline is dissolved in 50 ml of acetone at 40° C., and 22.4 g of KOH powder are added. The reaction mixture is kept at reflux for 30 minutes, filtered and evaporated on a rotary evaporator. The oily residue is rectified. 15 g of N-butyltrifluoroacetyl-2,4-difluoroaniline are obtained as a yellowish oil which distills at 106 - 110°/11.7 mbar.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05026625 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-7f930598a23248f4aa016acf3a6999fc |
| Source note | uspto-grants-1991_06 |