Diisopropylamine → 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

Participants

Reaction Steps

Diisopropylamine (156 millimoles) was dissolved in 80 ml of diethyl ether, and then 34.7 millimoles of beta-cyanoethoxydichlorophosphine was added. The mixture was stirred at room temperature for 12 hours. After the reaction, the resulting diisopropyl ammonium chloride was separated by filtration. The ether solution was distilled to give beta-cyanoethoxymonochloro(N,N-diisopropylamino) phosphine as an oil. The yield was 73 mole%, and the product had a boiling point of 102 to 104° C. (0.08 mmHg).

Provenance & Evidence