Hydrochloric Acid → N-(1-benzylpiperid-4-yl)-2-hydroxy-4-acetamido-5-nitrobenzamide

Participants

Reaction Steps

A mixture of N-(1-benzylpiperid-4-yl)-2-acetoxy-4-acetamido-5-nitrobenzamide (1.4 g; 0.0031 moles) [prepared by the procedure described in Example 1], sodium hydroxide (0.3 g; 0.0062 moles), water (25 ml) and ethanol (12.5 ml) was boiled under reflux for 3 hours. Then the mixture was diluted with water, neutralized with diluted hydrochloric acid and the solid filtered off, washed with water and diethyl ether to give 1.1 g of N-(1-benzylpiperid-4-yl)-2-hydroxy-4-acetamido-5-nitrobenzamide, m.p. 220°-222° C.

Provenance & Evidence