Acetic acid, bromo-, propyl ester → 2-Propoxycarbonylmethyl-4,5-dimethyl-2-oxo-1,3,2-dioxaphospholane

HRID 1494564Notes

Reaction equation

HRID 1494564 reaction equation
Br[CH2:2][C:3]([O:5][CH2:6][CH2:7][CH3:8])=[O:4].C[O:10][P:11]1[O:15][CH:14]([CH3:16])[CH:13]([CH3:17])[O:12]1>>[CH2:6]([O:5][C:3]([CH2:2][P:11]1(=[O:10])[O:15][CH:14]([CH3:16])[CH:13]([CH3:17])[O:12]1)=[O:4])[CH2:7][CH3:8]

Participants

3

Reactant 2

HCID 141981Acetic acid, bromo-, propyl esterHCID 2717332-Methoxy-4,5-dimethyl-1,3,2-dioxaphospholane

Product 1

HCID 198285872-Propoxycarbonylmethyl-4,5-dimethyl-2-oxo-1,3,2-dioxaphospholaneYield 95.1%

Procedure

Using the procedure of Step A of Example 1, 3.8 g of n-propyl bromoacetate and 2.42 g of 2-methoxy-4,5-dimethyl -1,3,2-dioxaphospholane were reacted to obtain 3.62 g of raw 2-propoxycarbonylmethyl-4,5-dimethyl-2-oxo-1,3,2-dioxaphospholane which was used as is for the next step.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-ea7329280bb9478ca866605e4110c141
Source dataset
uspto-grants-1991_06
Patent number
US05026862

Reaction notes

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