Isopropyl bromoacetate → 2-Isopropoxycarbonylmethyl-4,5-dimethyl-2-oxo-1,3,2-dioxaphospholane

HRID 1494566Notes

Reaction equation

Br[CH2:2][C:3]([O:5][CH:6]([CH3:8])[CH3:7])=[O:4].C[O:10][P:11]1[O:15][CH:14]([CH3:16])[CH:13]([CH3:17])[O:12]1>>[CH:6]([O:5][C:3]([CH2:2][P:11]1(=[O:10])[O:15][CH:14]([CH3:16])[CH:13]([CH3:17])[O:12]1)=[O:4])([CH3:8])[CH3:7]

Participants

Reactant 2

HCID 121593Isopropyl bromoacetate

HCID 2717332-Methoxy-4,5-dimethyl-1,3,2-dioxaphospholane

Product 1

HCID 198285902-Isopropoxycarbonylmethyl-4,5-dimethyl-2-oxo-1,3,2-dioxaphospholaneYield 94.8%

Procedure

Using the procedure of Step A of Example 1, 2.03 g of isopropyl bromoacetate and 1.3 g of 2-methoxy-4,5-dimethyl-1,3,2-dioxaphospholane were reacted to obtain 1.94 g of raw 2-isopropoxycarbonylmethyl-4,5-dimethyl-2-oxo-1,3,2-dioxaphospholane used as is for the next step.

Workup

customwere reacted

Sources & evidence

ORD record: ord-63e9c6512e604e2fa45c15ef9f805489
Source dataset: uspto-grants-1991_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05026862

Reaction notes

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