3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde → HCID 86603323, compound

HRID 14946Notes

Reaction equation

HRID 14946 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=2)[CH:11]=O)[CH:5]=[CH:4][N:3]=1.[CH2:16]([O:23][C:24]([N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH:27]1[C:32]#[N:33])=[O:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH2:16]([O:23][C:24]([N:26]1[CH2:31][CH2:30][N:29]([CH2:11][C:10]2[CH:13]=[CH:14][CH:15]=[C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[N:7]=3)[CH:9]=2)[CH2:28][CH:27]1[C:32]#[N:33])=[O:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 249019653-(2-Chloro-pyrimidin-4-yl)-benzaldehydeHCID 670451192-Cyano-piperazine-1-carboxylic acid benzyl ester

Product 1

HCID 86603323HCID 86603323, compound

Procedure

Intermediate 1 was coupled with 2-cyano-piperazine-1-carboxylic acid benzyl ester (generated according to literature procedure (ref 4)) following procedure B. LC-MS showed the product had the expected M+H+ of 448.

Sources & evidence

ORD record
ord-1ce7d573b1094b9f9a6dfa56140d0a4d
Source dataset
uspto-grants-2010_06
Patent number
US07732444B2

Reaction notes

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