Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1494729Generated: October 30, 2026

1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 14795759, compound

https://huagongshe.com/reaction/1494729

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,8-Diazabicyclo(5.4.0)undec-7-eneHCID 81184—
Reactant1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acidHCID 535414—
Reactant2,3-Dihydro-1H-isoindol-4-ol hydrobromideHCID 19828494—
SolventDimethylformamideHCID 6228—
ProductHCID 14795759HCID 1479575919.3%

Reaction Steps

136 mg of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 130 mg of 4-hydroxyisoindoline hydrobromide, 114 mg of 1,8-diazabicyclo[5,4,0]-7-undecene (DBU), and 1.5 ml of anhydrous DMF were processed in the same manner as in Example 1 to produce 37 mg of the target compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05026856
Source datasetuspto-grants-1991_06
ORD IDord-76b43d9863f9448c865ad9bd6884c4e2
Source noteuspto-grants-1991_06