HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → 7-(4-Amino-2-isoindolinyl)-1-ethyl-6-fluoro-1 4-dihydro-4-oxoquinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 800521 | — |
| Reactant | Isoindolin-4-amine | HCID 14795861 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-(4-Amino-2-isoindolinyl)-1-ethyl-6-fluoro-1 4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 14795806 | 54.9% |
Reaction Steps
177 mg of 1-ethyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 282 mg of 4-amino-isoindoline, and 1.5 ml of anhydrous DMF were processed in the same manner as in Example 2 to produce 141 mg of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05026856 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-1b7b75d10d164f259575cef83e9a7568 |
| Source note | uspto-grants-1991_06 |