HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2,4-Difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → HCID 14795821, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2,4-Difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 14476011 | — |
| Reactant | 4-fluoro-2,3-dihydro-1H-isoindole | HCID 14795867 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 14795821 | HCID 14795821 | 81.9% |
Reaction Steps
180 mg of 1-(2,4-difluorophenyl)-6,7,8-trifluoro-1,4- dihydro-4-oxoquinoline-3-carboxylic acid, 210 mg of 4-fluoroisoindoline, and 1.5 ml of anhydrous DMF were processed in the same manner as in Example 20 to produce 196 mg of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05026856 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-6b9f6fdb241b4e359f254efb7c396e5e |
| Source note | uspto-grants-1991_06 |