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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1494791Generated: October 30, 2026

1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 14795832, compound

https://huagongshe.com/reaction/1494791

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,8-Diazabicyclo(5.4.0)undec-7-eneHCID 81184—
Reactant1-(4-Fluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acidHCID 13728330—
Reactant2,3-Dihydro-1H-isoindol-4-ol hydrobromideHCID 19828494—
SolventDimethylformamideHCID 6228—
ProductHCID 14795832HCID 1479583223.5%

Reaction Steps

178 mg of 1-(4-fluorophenyl)-6,7,8-trifluoro-1,4- dihydro-4-oxoquinoline-3-carboxylic acid, 130 mg of 4-hydroxyisoindoline hydrobromide, 137 mg of DBU, and 1.5 ml of anhydrous DMF were processed in the same manner as in Example 20 to produce 56 mg of the target compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05026856
Source datasetuspto-grants-1991_06
ORD IDord-d6cea3e59e78453dab61dfabf86ce3cc
Source noteuspto-grants-1991_06