HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 14795815, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 1-Ethyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 9835179 | — |
| Reactant | methyl 2,3-dihydro-1H-isoindole-5-carboxylate hydrochloride | HCID 19828495 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 14795815 | HCID 14795815 | 28.5% |
Reaction Steps
271 mg of 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4- oxoquinoline-3-carboxylic acid, 217 mg of 5-methoxycarbonylisoindoline hydrochloride, 457 mg of DBU, and 3ml of anhydrous DMF were processed in the same manner as in Example 20 to produce 122 mg of the target compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05026856 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-e5bbeb75029c4bc99a68de8046d45551 |
| Source note | uspto-grants-1991_06 |