反应详情

11.5 g of 2-benzyl-4-nitroisoindoline was dissolved in 150 ml of methanol and to the solution was added 1.5 g of 10% palladium on carbon. The mixture was stirred under a hydrogen gas stream under atmospheric pressure for one day at room temperature and for another 5 days at 40° C.. The catalyst was removed by filtration and the filtrate was concentrated. The residue was purified by a vacuum distillation (bath temperature: 150°-180° C., pressure: 0.1 mmHg) to obtain 3.74 g of 4-aminoisoindoline.

1. waitfor another 5 days at 40° C.
2. customThe catalyst was removed by filtration
3. concentrationthe filtrate was concentrated
4. distillationThe residue was purified by a vacuum distillation (bath temperature: 150°-180° C., pressure: 0.1 mmHg)