反应详情

400 mg of 10% palladium on carbon was added to 2.17 g of 2-benzyl-5-ethylaminoisoindoline prepared above in 30 ml of methanol and catalytic hydrogenation was carried out at 45° C. for 7 days. After removing the catalyst by filtration, the filtrate was concentrated and purified by vacuume distillation (bath temperature: 160°-200° C., pressure: 0.1 mmHg) to obtain 950 mg of 5-ethylaminoisoindoline.

1. customAfter removing the catalyst
2. filtrationby filtration
3. concentrationthe filtrate was concentrated
4. distillationpurified by vacuume distillation (bath temperature: 160°-200° C., pressure: 0.1 mmHg)