2-Benzyl-5-ethylaminoisoindoline → 5-Ethylaminoisoindoline

HRID 1494831Notes

Reaction equation

HRID 1494831 reaction equation
C([N:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([NH:17][CH2:18][CH3:19])[CH:14]=2)[CH2:9]1)C1C=CC=CC=1>[Pd].CO>[CH2:18]([NH:17][C:13]1[CH:14]=[C:15]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:16]2)[CH3:19]

Participants

4

Reactant 1

HCID 151678892-Benzyl-5-ethylaminoisoindoline

Product 1

HCID 147958635-EthylaminoisoindolineYield 68.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

400 mg of 10% palladium on carbon was added to 2.17 g of 2-benzyl-5-ethylaminoisoindoline prepared above in 30 ml of methanol and catalytic hydrogenation was carried out at 45° C. for 7 days. After removing the catalyst by filtration, the filtrate was concentrated and purified by vacuume distillation (bath temperature: 160°-200° C., pressure: 0.1 mmHg) to obtain 950 mg of 5-ethylaminoisoindoline.

Workup

  1. customAfter removing the catalyst
  2. filtrationby filtration
  3. concentrationthe filtrate was concentrated
  4. distillationpurified by vacuume distillation (bath temperature: 160°-200° C., pressure: 0.1 mmHg)

Sources & evidence

ORD record
ord-a4dc9e666953490bbe4d2a1c421461c5
Source dataset
uspto-grants-1991_06
Patent number
US05026856

Reaction notes

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