2,3-Dihydro-4-methoxy-2-(phenylmethyl)-1H-isoindole → 4-methoxy-2,3-dihydro-1H-isoindole

Participants

Reaction Steps

1.5 g of 10% palladium on carbon was added to a solution of 8.5 g of 2-benzyl-4-methoxyisoindoline in 100 ml of methanol and hydrogenation was performed at 45° C. for 7 days. After removing the catalyst by filtration, the filtrate was concentrated and purified by vacuum distillation (bath temperature: 160°-180 ° C., pressure: 0.1 mmHg) to obtain 3.44 g of 4-methoxyisoindoline.

Provenance & Evidence