HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → 4-fluoro-2,3-dihydro-1H-isoindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Propionic Acid | HCID 1032 | — |
| Reactant | HCID 15167892 | HCID 15167892 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | 4-fluoro-2,3-dihydro-1H-isoindole | HCID 14795867 | 55.8% |
Reaction Steps
The procedure described in Reference Example 6-(3) was followed using 2.30 g of 2-(p-toluenesulfonyl)-4-fluoroisoindoline, 2.30 g of phenol, 20 ml of 48% hydrobromic acid, and 3.5 ml of propionic acid. Purification of the crude product by vacuum distillation (bath temperature: 110°-150° C., pressure: 7 mmHg) gave 604 mg of 4-fluoroisoindoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05026856 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-f63a0bf8385249e9b7243b9591cd92ac |
| Source note | uspto-grants-1991_06 |