HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 5-Bromoisoindoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Phenol | HCID 996 | — |
| Reactant | 5-Bromo-2-(p-tolylsulfonyl)isoindoline | HCID 15167898 | — |
| Solvent | Propionic Acid | HCID 1032 | — |
| Product | 5-Bromoisoindoline | HCID 14795871 | 34.7% |
Reaction Steps
The procedure of Reference Example 6-(3) was followed using 12.8 g of 2-(p-toluenesulfonyl)-5-bromoisoindoline, 12 g of phenol, 160 ml of 48% hydrobromic acid, and 30 ml of propionic acid. Purification of the crude product by vacuum distillation gave 2.5 g of 5-bromoisoindoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05026856 |
| Source dataset | uspto-grants-1991_06 |
| ORD ID | ord-6939f8db48284c3c8f0e9c9887411778 |
| Source note | uspto-grants-1991_06 |