2-Benzyl-5-methoxy-2,3-dihydro-1H-isoindole → 5-methoxy-2,3-dihydro-1H-isoindole

Participants

Reaction Conditions

Reaction Steps

1.5 g of 10% palladium on carbon was added to a solution of 12.5 g of 2-benzyl-5-methoxyisoindoline prepared above in 150 ml of methanol and the mixture was stirred under hydrogen gas stream at 40° C. under atmospheric pressure for 7 days. After removing the catalyst by filtration, the filtrate was concentrated and purified by vacuum distillation to give 4.7 g of 5-methoxyisoindoline.

Provenance & Evidence