L-Glutamine → HCID 61181145, compound

HRID 1496662Notes

Reaction equation

HRID 1496662 reaction equation
[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6].[CH2:11]([N:18]=[C:19]=[O:20])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH2:11]([NH:18][C:19]([NH:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6])=[O:20])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 5961L-GlutamineHCID 76639Benzyl isocyanate

Product 1

HCID 61181145HCID 61181145, compoundYield 68%

Procedure

Preparation from L-(+)-glutamine (5.39 g, 36.9 mmol) and benzyl isocyanate (4.96 g, 36.9 mmol) (final pH value after 24 h stirring: 8-9) gave N2-[(benzylamino)carbonyl]-L-glutamine (7.0 g, 68%, white solid).

Sources & evidence

ORD record
ord-c31398bb40bf475f900faebf832903cf
Source dataset
uspto-grants-2015_12
Patent number
US09198845B2

Reaction notes

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