Dapagliflozin → HCID 131728579, compound

HRID 1496718Notes

Reaction equation

HRID 1496718 reaction equation
[CH3:1][CH2:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11]2[CH:12]=[C:13]([C@@H:18]3[O:23][C@H:22]([CH2:24][OH:25])[C@@H:21]([OH:26])[C@H:20]([OH:27])[C@H:19]3[OH:28])[CH:14]=[CH:15][C:16]=2[Cl:17])=[CH:8][CH:9]=1.[CH3:29][CH2:30][O:31][C:32]1[CH:37]=[CH:36][C:35]([CH2:38][C:39]2[CH:44]=[C:43]([CH:45]3[O:50][C@H:49]([CH2:51][OH:52])[C@@H:48]([OH:53])[C@H:47]([OH:54])[C@H:46]3[OH:55])[CH:42]=[CH:41][C:40]=2[Cl:56])=[CH:34][CH:33]=1.[CH3:57][C@H:58]([OH:61])[CH2:59][OH:60].[OH2:62]>>[CH3:1][CH2:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]2[CH:12]=[C:13]([C@@H:18]3[O:23][C@H:22]([CH2:24][OH:25])[C@@H:21]([OH:26])[C@H:20]([OH:27])[C@H:19]3[OH:28])[CH:14]=[CH:15][C:16]=2[Cl:17])=[CH:6][CH:5]=1.[CH3:29][CH2:30][O:31][C:32]1[CH:37]=[CH:36][C:35]([CH2:38][C:39]2[CH:44]=[C:43]([CH:45]3[O:50][C@H:49]([CH2:51][OH:52])[C@@H:48]([OH:53])[C@H:47]([OH:54])[C@H:46]3[OH:55])[CH:42]=[CH:41][C:40]=2[Cl:56])=[CH:34][CH:33]=1.[CH3:57][C@H:58]([OH:61])[CH2:59][OH:60].[OH2:62]

Participants

3

Reactant 2

HCID 9887712DapagliflozinHCID 56841155HCID 56841155, compound

Product 1

HCID 131728579HCID 131728579, compound

Procedure

Tablets containing the SGLT2 inhibitor dapagliflozin or dapagliflozin propylene glycol hydrate were prepared in strengths of 2.5 mg (Example 7), 10 mg (Example 8) and 50 mg (Example 9) as described below.

Workup

  1. customwere prepared in strengths of 2.5 mg (Example 7), 10 mg (Example 8) and 50 mg (Example 9)

Sources & evidence

ORD record
ord-199cdbb6cead499e83451f8b3b84a3be
Source dataset
uspto-grants-2015_12
Patent number
US09198925B2

Reaction notes

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