HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Treprostinil diolamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Diethanolamine | HCID 8113 | — |
| Reactant | Treprostinil | HCID 6918140 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Treprostinil diolamine | HCID 11179459 | — |
Reaction Steps
Treprostinil acid is dissolved in a 1:1 molar ratio mixture of ethanol:water and diethanolamine is added and dissolved. The solution is heated and acetone is added as an antisolvent during cooling.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199908B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-a1cdaa99561e4b04b60b228e2a01911b |
| Source note | uspto-grants-2015_12 |