Stannous chloride dihydrate → HCID 68588616, compound

Participants

Reaction Steps

A solution of 18.00 g (57.6 mmol) of 4-(3,4-dichlorophenoxy)-2,5-dimethylnitrobenzene in 40 ml of dioxane and 40 ml of hydrochloric acid is admixed with 39.0 g (173.0 mmol) of tin(II) chloride dihydrate at room temperature and then refluxed for 2 h. It is cooled to room temperature, neutralized with NaHCO3 and extracted repeatedly with dichloromethane, and the extracts are dried over Na2SO4 and filtered, and the solvent is removed under reduced pressure (18.3 g, 89% purity, 99.5% yield, log P (pH 2.3)=3.51).

Provenance & Evidence