Butylamine → HCID 59289846, compound

Participants

Reaction Steps

20.8 g (0.08 mol) of 6-(4-methoxy-benzoyl)-7-oxa-bicyclo[4.2.0]octan-8-one (example 10) are dissolved in 200 ml of tert-butyl methyl ether. 10.46 g (0.143 mol) of n-butylamine are slowly added to this solution over one hour. The reaction mixture is stirred overnight at room temperature and the solvent is subsequently distilled off under vacuum. The yellowish oil thus obtained crystallizes upon standing and is purified by recrystallization from heptane. 22.5 g (85%) 2-(4-methoxybenzoyl)-2-hydroxy-cyclohexanecarboxylic acid butyl-amide are thus obtained as white solid with a melting point of 94-95° C.

Provenance & Evidence