HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1496843Generated: October 31, 2026
Tetrabutylammonium Fluoride → HCID 86676102, compound
https://huagongshe.com/reaction/1496843
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | HCID 71237756 | HCID 71237756 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86676102 | HCID 86676102 | 72.4% |
Reaction Steps
1N tetrabutylammonium fluoride (TBAF) in THF was added to 1.71 g (3,5-Difluoro-4-methoxy-phenylethynyl)-trimethyl-silane and the mixture stirred at 25° C. overnight. The solvent was removed in vacuo and the residue purified by flash chromatography over silica eluting with 20:1 heptane:ethyl acetate to give 866 mg 5-Ethynyl-1,3-difluoro-2-methoxy-benzene in 72% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09199937B2 |
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| Source dataset | uspto-grants-2015_12 |
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| ORD ID | ord-ad43e018f6684aa797d5b66018d817a1 |
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| Source note | uspto-grants-2015_12 |
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