Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-(Hydroxymethyl)-5,5-dimethylhydantoin | HCID 67000 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 12873573 | HCID 12873573 | — |
Reaction Steps
0.69 ml Thionyl chloride was added to a solution of 500 mg 1-Hydroxymethyl-5,5-dimethyl-imidazolidine-2,4-dione in 5 ml DCM at 0° C. for 30 minutes, then left to stir at 25° C. for 16 hours. The mixture was evaporated to dryness and used crude in the synthesis of example 23.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09199937B2 |
|---|
| Source dataset | uspto-grants-2015_12 |
|---|
| ORD ID | ord-1503ffc39fd84a84ba289239b9d4477a |
|---|
| Source note | uspto-grants-2015_12 |
|---|
