Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-Methylacetamide | HCID 6582 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 4-Bromobenzyl bromide | HCID 68527 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 12839032 | HCID 12839032 | 96.3% |
Reaction Steps
1.316 g N-methylacetamide was dissolved in 60 mL THF. 2.02 g Potassium tert-butoxide was added and the mixture stirred for 20 min at 50° C. Then 3 g of 4-bromobenzylbromide dissolved in 10 mL THF was added and the mixture stirred for 2 h at 50° C. After cooling ethylacetate and water were added and the organic phase extracted with water (1×), dried and the solvent distilled off to yield 2.8 g N-(4-bromobenzyl)-N-methylacetamide as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09199937B2 |
|---|
| Source dataset | uspto-grants-2015_12 |
|---|
| ORD ID | ord-56e1f18917de4d3e9cae9d7c1d948da0 |
|---|
| Source note | uspto-grants-2015_12 |
|---|
