HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 2-((7-Bromoquinolin-5-yloxy)methyl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Di-tert-butyl azodicarboxylate | HCID 97268 | — |
| Reactant | 2-(Hydroxymethyl)pyridine-3-carboxamide | HCID 13929518 | — |
| Reactant | 7-Bromoquinolin-5-ol | HCID 136216619 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-((7-Bromoquinolin-5-yloxy)methyl)nicotinamide | HCID 71237775 | 45% |
Reaction Steps
100 mg 7-Bromo-quinolin-5-ol, 77.5 mg of 2-(hydroxymethyl)nicotinamide 3.7, 233.5 mg of triphenylphosphine and 205 mg of Di-tertbutyl-azodicarboxylate (DBAD) were dissolved in 2.5 mL of DCM and 7.5 mL of THF under Argon at room temperature. After 14 h the precipitate was collected and dried. The mother liquor was concentrated and the formed precipitate again collected to yield 72 mg Example 22.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199937B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-d500ee0a7eb943658494ddda191f802a |
| Source note | uspto-grants-2015_12 |