Potassium Carbonate → 1-(4-(3-Ethoxy-4-nitrophenyl)piperazin-1-yl)ethanone

HRID 1496945ノート

反応式

HRID 1496945 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([O:11][CH2:12][CH3:13])[CH:3]=1.[C:14]([N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1)(=[O:16])[CH3:15].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:12]([O:11][C:4]1[CH:3]=[C:2]([N:20]2[CH2:21][CH2:22][N:17]([C:14](=[O:16])[CH3:15])[CH2:18][CH2:19]2)[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9])[CH3:13]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 837951-AcetylpiperazineHCID 129181532-Ethoxy-4-fluoronitrobenzene

生成物 1

HCID 1181057541-(4-(3-Ethoxy-4-nitrophenyl)piperazin-1-yl)ethanone

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The compound obtained in Step 1 above (300 mg), N-acetylpiperazine (300 mg), and potassium carbonate (500 mg) were dissolved in dimethylformamide (3 mL) and reacted at 80° C. overnight. The dimethylformamide of the reaction mixture was removed under reduced pressure, and added with water to form a solid. The solid was filtered to obtain a target compound as a yellow solid.

後処理

  1. customreacted at 80° C. overnight
  2. customThe dimethylformamide of the reaction mixture was removed under reduced pressure
  3. additionadded with water
  4. customto form a solid
  5. filtrationThe solid was filtered

出典と根拠

ORDレコード
ord-2c8e1a83285440b6b1edfc06111e3ca8
出典データセット
uspto-grants-2015_12
特許番号
US09199944B2

反応ノート

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