HCID 90383149, compound → 1-[4-(4-Amino-3-chlorophenyl)piperazin-1-yl]ethan-1-one
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:11]2[CH2:16][CH2:15][N:14]([C:17](=[O:19])[CH3:18])[CH2:13][CH2:12]2)[CH:5]=[CH:6][C:7]=1[N+:8]([O-])=O>C(O)C>[NH2:8][C:7]1[CH:6]=[CH:5][C:4]([N:11]2[CH2:16][CH2:15][N:14]([C:17](=[O:19])[CH3:18])[CH2:13][CH2:12]2)=[CH:3][C:2]=1[Cl:1]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 90 °C
Procedure
The compound prepared in Step 1 was dissolved in ethanol (10 ml) and distilled water (1.0 ml), added with iron (powder, 2.0 g) and ammonium chloride (1.0 g), and stirred at 90° C. for 2 hours. Then, the resultant was filtered using celite and the filtrate was distilled under reduced pressure to remove the solvent. The resulting white solid was used in the subsequent reaction without further purification.
Workup
- distillationdistilled water (1.0 ml)
- additionadded with iron (powder, 2.0 g) and ammonium chloride (1.0 g)
- filtrationThen, the resultant was filtered
- distillationthe filtrate was distilled under reduced pressure
- customto remove the solvent
- customThe resulting white solid was used in the subsequent reaction without further purification
Sources & evidence
- ORD record
- ord-ba5414df8f934728aa66e9826a823895
- Source dataset
- uspto-grants-2015_12
- Patent number
- US09199944B2
Reaction notes
Loading…