HCID 118105693, compound → HCID 118105758, compound

HRID 1496960Notes

Reaction equation

HRID 1496960 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:12][CH2:11]2)=[CH:6][C:5]=1[O:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([O:18][C:19]([CH3:22])([CH3:20])[CH3:21])=[O:17])[CH2:12][CH2:11]2)=[CH:6][C:5]=1[O:23][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

4

Reactant 1

HCID 118105693HCID 118105693, compound

Product 1

HCID 118105758HCID 118105758, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The compound prepared in Step 2 was dissolved in ethanol, added with 10% Pd/C and stirred under hydrogen atmosphere for 2 hours. Upon completion of the reaction, the Pd/C in the reaction mixture was removed using celite and the solvent was removed under reduced pressure. The thus obtained compound was used in the subsequent reaction without further purification.

Workup

  1. customUpon completion of the reaction
  2. customthe Pd/C in the reaction mixture was removed
  3. customthe solvent was removed under reduced pressure
  4. customThe thus obtained compound was used in the subsequent reaction without further purification

Sources & evidence

ORD record
ord-358c29b99f864cd6ae15944e43920963
Source dataset
uspto-grants-2015_12
Patent number
US09199944B2

Reaction notes

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