HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1496963Generated: October 30, 2026
Ammonium Chloride → Tert-butyl 4-(4-amino-3-fluorophenyl)piperazine-1-carboxylate
https://huagongshe.com/reaction/1496963
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Tert-butyl 4-(3-fluoro-4-nitrophenyl)piperazine-1-carboxylate | HCID 66738172 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | Tert-butyl 4-(4-amino-3-fluorophenyl)piperazine-1-carboxylate | HCID 57652076 | — |
Reaction Steps
The compound prepared in Step 1 was dissolved in ethanol (10 ml) and water (1.0 ml), added with iron (powder, 2.0 g) and ammonium chloride (1.0 g), and stirred at 80° C. for 2 hours. Then, the resultant was filtered with celite, distilled under reduced pressure to remove the solvent. The thus obtained target compound as a white solid was used in the subsequent reaction without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09199944B2 |
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| Source dataset | uspto-grants-2015_12 |
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| ORD ID | ord-13cd2cec0e334b1b8fd1548f8d53dbbe |
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| Source note | uspto-grants-2015_12 |
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