Potassium Carbonate → HCID 118105706, compound

Participants

Reaction Steps

2,4-dichloro-5-(trifluoromethyl)pyrimidine (800 mg) and potassium carbonate (510 mg) were dissolved in n-butanol (15 ml), dropwisely added with a reaction solution, in which 4-(4-amino-3-methoxyphenyl)piperazin-1-carboxylate (1.13 g) was dissolved in n-butanol (5 ml), and stirred at room temperature overnight. Then, the mixture was distilled under reduced pressure to remove the solvent, added with ethyl acetate, and washed with saturated brine. The washed organic layer was dried with sodium sulfate, and concentrated under reduced pressure. The concentrated mixture was purified by column chromatography to obtain a target compound (430 mg).

Provenance & Evidence