反应详情

1-(4-(4-amino-3-methoxyphenyl)piperazin-1-yl)ethanone (40 mg) prepared in Preparation Example 1 and 1-(4-(4-(2,5-dichloropyrimidine-4-ylamino)-3-ethoxyphenyl)piperazin-1-yl)ethanone (50 mg) prepared in Preparation Example 15 were dissolved in 0.08M HCl ethoxyethanol solution (1.2 mL), and allowed to react at 115° C. overnight. Upon completion of the reaction, the solvent of the mixture was removed under reduced pressure, diluted with ethyl acetate, neutralized with an aqueous saturated sodium carbonate solution, water was removed from the organic layer with sodium sulfate, and the solvent was removed under reduced pressure. The mixture was purified by column chromatography to obtain a target compound.

1. customprepared in Preparation Example 15
2. customto react at 115° C. overnight
3. customUpon completion of the reaction
4. customthe solvent of the mixture was removed under reduced pressure
5. additiondiluted with ethyl acetate
6. customwas removed from the organic layer with sodium sulfate
7. customthe solvent was removed under reduced pressure
8. customThe mixture was purified by column chromatography
9. customto obtain a target compound