HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-bromo-5-fluorobenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 3-Bromo-5-fluorobenzoic acid | HCID 2773339 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-bromo-5-fluorobenzoyl chloride | HCID 2783345 | — |
Reaction Steps
10 g of 3-bromo-5-fluoro-benzoic acid are suspended in 100 ml of DCM, 0.5 ml DMF and 4.5 ml oxalyl chloride (1.15 Eq) are added and the resulting mixture is stirred for 100 minutes at RT. The solvent is removed by vacuo and the benzoic acid chloride is isolated by distillation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09199947B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-66fa69f971064cbe863bd8e0e91ff497 |
| Source note | uspto-grants-2015_12 |