HCID 117600035, compound → HCID 86281946, compound

Participants

Reaction Steps

The racemic 3-(5′-Isopropyl-2′-methoxy-biphenyl-3-yl)-3-(5-methyl-[1,3,4]oxadiazol-2-yl)-propionic acid is subjected to chromatography on a chiral column using a heptane-methanol gradient to isolate the pure enantiomers (S)-3-(5′-Isopropyl-2′-methoxy-biphenyl-3-yl)-3-(5-methyl-[1,3,4]oxadiazol-2-yl)-propionic acid and (R)-3-(5′-Isopropyl-2′-methoxy-biphenyl-3-yl)-3-(5-methyl-[1,3,4]oxadiazol-2-yl)-propionic acid. The configuration on the chiral carbon atom is arbitrarily assigned (S) to the enantiomer with the shortest retention time on the applied chiral column and (R) to the enantiomer with the longest retention time on the applied chiral column.

Provenance & Evidence